Advancing mammalian genetics and biotechnology.
At PolyGene, innovative as well as standard methods allow for the production of animals carrying foreign genes in a predefined manner: as tissue-specific genes, as single-copy or multi-copy cluster, as fusion genes, or in inducible or repressible form.
Gene Regulation
Unique and powerful systems for inducible gene expression control. Glucocorticoid and antibiotic-driven (i.e. phloretin-, macrolide- or pristinamycin-inducible) gene regulation systems for your inducible transgenic mouse model project are available...
Nuclease Systems
Nuclease based engineering at PolyGene.
The field of genomic engineering is changing quickly during the last years. Beginning with custom zinc finger nucleases in 2009, a number of techniques have been established to facilitate the introduction of...
Tailor-made Knockout Mouse and Rat Models
Turning off rodent genes to elucidate their function or model genetic diseases.
Given the high similarity between rodent and human genomes, the laboratory mouse and rat are preferred model choices to understand biological mechanisms of genes and diseases...
Tailor-made Knock-in Mouse and Rat Models
Gene replacement and humanization by knock-in.
Gene targeting by knock-in can mean to generate a point mutation corresponding to a human morbid gene ; or to use the genomic regulation and insert a coding frame – a fluorescent marker, a recombinase, o...
Overexpression
Transgenic animal model - workhorse of mammalian genetics.
Innovative as well as standard methods allow for the production of animals carrying foreign genes in a predefined manner: as tissue-specific genes, as single-copy or multi-copy cluster, as...
Cryopreservation
The world's first life insurance for your valuable mouse strains.
PolyGene freeze internal strains, both, to have safe back-up , and to be able to maintain a minimal size of holding colonies . We found that even for actively managed mouse strains,...